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‏إظهار الرسائل ذات التسميات Hyperbaric Oxygen Therapy. إظهار كافة الرسائل
‏إظهار الرسائل ذات التسميات Hyperbaric Oxygen Therapy. إظهار كافة الرسائل

HBOT Autism Trial Demonstrates Clinical Improvements In Autistic Children


The US National Institutes of Health have released a summary report of a "Controlled Trial of the Clinical Effects of Hyperbaric Therapy in Autistic Children" by Dr. Daniel Rossignol last updated in July 2007 which purports to demonstrate that HBOT may improve symptoms in autistic children. The trial used HBOT in 18 children between the ages of 2 and 7 with DSM-IV Autistic Disorder diagnoses (PDD-NOS and Asperger's Syndrome were excluded). Dr. Rossignol claims that the trial demonstrates significant clinical improvements in the autistic children on several standardized scales.

The trial has some limitations in that most of the scales were parent-rated but the parents were not blinded to the fact that their children were receiving HBOT. There was no placebo or control group. The NIH summary indicates that these factors could lead to bias and that the improvements could have been due to chance or the natural development of the children and suggests the need for a double-blind controlled study.





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Pilot Study of HBOT Effect on Autism Symptoms Published

A pilot study of the effect of Hyperbaric Oxygen Therapy on autism symptoms, oxidative stress and inflammation has been published in BMC Pediatrics. In The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study Daniel A Rossignol , Lanier W Rossignol , S. Jill James , Stepan Melnyk and Elizabeth Mumper report their findings and conclusions from a study of 18 children with autism aged 3-16 who underwent 40 hyperbaric sessions of 45 minutes duration each at either 1.5 atmospheres (atm) and 100% oxygen, or at 1.3 atm and 24% oxygen. On safety issues the authors report that maximum pressure of 1.5 atm with up to 100% oxygen was safe and well tolerated. In terms of improvements the report indicates, as set out in the abstract, that "HBOT significantly decreased inflammation as measured by CRP levels. Parental observations support anecdotal accounts of improvement in several domains of autism." The authors of the paper note that this was an "open label" study and "definitive statements regarding the efficacy of HBOT for the treatment of individuals with autism must await results from double-blind, controlled trials".

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